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Course Objectives: The goal of this program is to provide nurses with information on preventing surgical site infections (SSIs). After studying the information presented here, you will be able to: Explain why prophylactic antibiotics should be given 30 to 60 minutes before incision and discontinued within 24 hours after surgery. Discuss why giving antibiotics after wound closure does not prevent infections. Discuss why hypothermia and hyperglycemia are included in Joint Commission core measures for preventing SSIs.