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Course Objectives: The goal of this program is to inform nurses of the severity and causes of central venous catheter-associated bloodstream infections and to describe the Central Line Bundle, a group of evidence-based interventions. After studying the information presented here, you will be able to: Describe the severity of central venous catheter-associated bloodstream infections. Explain the causes and risk factors of central venous catheter-related bloodstream infections. Name the five components of the Central Line Bundle.